Smoking may trigger migraine attacks27 because cigarette smoke may act as an agonist of transient receptor potential ankyrin 1 (TRPA1) channels,28 which upon activation mediate release of calcitonin gene-related peptide (CGRP)—a key molecule in migraine pathophysiology.29 As our cohort is substantially older than other study populations,30 we hypothesize that the association of current smoking and a lower migraine prevalence stems from lifestyle (behavioral) choices. Here, TRPA1 is linked to migraine disorder.