In addition, CGRP—as mentioned above causally linked to migraine34—has a suppressive role on insulin release.35 Another hypothesis is that developing diabetes could lead to impairment of sensory nerves, with a subsequent reduction of the vasodilatory and nociceptive effects of CGRP and a lower migraine prevalence.36,37 We only found an inverse association between diabetes mellitus and migraine in females and, although we assume that most of the females in our study were postmenopausal (average age of 67 years), sex hormones might potentially be involved in this study.38 Here, INS is linked to diabetes mellitus.