CERS6 and cancer: Silencing Cer synthase 6 (CERS6) inhibits the migration of A549 cells, which is reversed by the addition of exogenous C16 Cer, suggesting the increase in the migratory ability of A549 cells compared to that of the same cells lacking C16 Cer, thus indicating that C16 Cer increases the migration of cancer cells.58, 59