However, LPKO LCLs derived from Pan B cells come from memory B cells that in some way compensate for the absence of EBNA-LP unlike naïve B cells, and as such observed differences may in part be attributed to distinct functions of YY1 in the survival of naïve but not memory B cells–and more distinct differences in EBNA-LP-dependent YY1 activity may occur earlier during EBV infection of naïve B cells. Here, YY1 is linked to Epstein-Barr virus infection.