HSPA5 and neurodegenerative disease: The transcripts Scn7a played regulatory roles in diabetic neuropathic pain [47]; Txnip was the key factor to cause SC dysfunction in DPN [48]; Sptbn1 was involved in neurodegenerative diseases and exhibited roles in regulating axonal transport and neurite growth [49]; Hspa1b, Hspa5 and Hsp90b1 belonged to heat shock protein genes, Hspa1b had anti-apoptotic role to protect cells from multiple proapoptotic stimuli [40], and the latter two transcripts could be activated by the ER stress [44].