Enhancer of zeste homolog 2 (EZH2) expression in SCLC cells is associated with the epigenetic silencing of TGFβRII expression, TGFβ‐SMAD‐ASCL1 (achaete‐scute family bHLH transcription factor 1) pathway suppression, and contributing to SCLC progression. The gene discussed is ASCL1; the disease is small cell lung carcinoma.