Furthermore, MYC and PI3K‐Akt signaling pathway have synergistical effect in enhancing tumor growth.[42] Gene set enrichment analyses on sulfated ECM‐induced network revealed pathways regulating carcinogenesis of many cancer types, cell cycle, PI3K‐Akt signaling and most interestingly PG signaling (Figure 6d). This evidence concerns the gene PIK3CA and cancer.