In contrast, we observed an upregulation of epithelial marker E‐cadherin on both protein (Figure 3a) and gene (CDH1) (Figure 3b) levels in sulfated hydrogels, indicating a lack of conventional “cadherin‐switch” but a more dynamic transition between epithelial‐mesenchymal states normally observed in metastatic tumor cells.[27, 28] Besides, E‐cadherin is a promoter of spheroid formation correlating with the increased number of clusters in sulfated hydrogels which exhibit localization of E‐cadherin in the periphery (Figure 3a). The gene discussed is CDH1; the disease is neoplasm.