Network analysis identified the interaction of RYK receptor with beta‐catenin (CTNNB1) that plays a crucial role in lung cancer stem cell phenotype, in line with our experimental data demonstrating its elevated expression in S‐AlgLung hydrogels (Figure 3f).[38] Moreover, MYC and MYCN, located downstream of PIK3CA in the reconstructed network, are known to be deregulated in lung cancer.[42] Activated MYC is an inducer of EMT which can interact with regulators including SNAIL and TWIST. Here, MYCN is linked to lung carcinoma.