In this context, HNF4a or estrogen‐related receptor alpha (ESRRA) is modified during AKI.[58] FOXK1 has multiple effects on cellular metabolism through transcriptional regulation of a panel of target genes.[27, 31, 57] We herein report that FOXK1 boosts glycolysis in TECs by promoting a set of gene expressions, including Slc2a2, Hk1, Fbp1, Aldoa, Bpgm, Ldhc, Hk2, Pkm2, and Ldha. This evidence concerns the gene LDHA and acute kidney injury.