In the UUO and IRI murine models, a notable alleviation of renal fibrosis was observed in the AAV9‐shFoxk1‐treated mice but not the AAV‐shCtrl mice (Figure 8E,F; Figure S8B,C, Supporting Information), manifested by the accumulation of extracellular matrix (Figure 8G–I; Figure S8D–F, Supporting Information) and fibrotic markers (Fibronectin and α‐SMA) expression (Figure 8J; Figure S8G, Supporting Information, and Figure S9, Supporting Information). This evidence concerns the gene ACTA1 and renal fibrosis.