From our analysis results, the 12 genes (MCM4, POLA1, MCM6, MCM3, RBBP4, DNA2, AP2B1, KIF11, KIF23, TUBA1B, KIF14, NUDT21) in HCC tissues have significant expression differences, and also affect the overall survival rate of patients. This evidence concerns the gene RBBP4 and hepatocellular carcinoma.