From our analysis results, the 12 genes (MCM4, POLA1, MCM6, MCM3, RBBP4, DNA2, AP2B1, KIF11, KIF23, TUBA1B, KIF14, NUDT21) in HCC tissues have significant expression differences, and also affect the overall survival rate of patients. Here, TUBA1B is linked to hepatocellular carcinoma.