Visceral adipocytes isolated from women with obesity showed that during 24 h, Bmal1 expression changes in the first 12 h in visceral adipocytes compared with lean women, while Rev-reb and Cry2 expression is up-regulated during the 24 h in visceral and subcutaneous adipocytes [46]. Here, BMAL1 is linked to obesity due to melanocortin 4 receptor deficiency.