Visceral adipocytes isolated from women with obesity showed that during 24 h, Bmal1 expression changes in the first 12 h in visceral adipocytes compared with lean women, while Rev-reb and Cry2 expression is up-regulated during the 24 h in visceral and subcutaneous adipocytes [46]. The gene discussed is CRY2; the disease is obesity due to melanocortin 4 receptor deficiency.