It is not clear whether this diminished activitywould affect the susceptibility of cells harboring fluoroquinoloneresistance mutations in both gyrase and topoisomerase IV to SPTs.However, because gyrase is the primary cellular target of zoliflodacinin N. gonorrhoeae cells,60 it is likely that the SPT would maintain itsactivity against these fluoroquinolone-resistant infections. Here, AGXT is linked to infection.