Differentially regulated genes were enriched for classical lymphoma driver genes downstream of the BCR, including MALT1 and CARD11, as well as NFATC2, TNFRSF13C (BAFF), and components of the NF-κB (RELB, IRAK1, BCL3, and TNFRSF1B) pathway (Figure 4I). The gene discussed is IRAK1; the disease is lymphoma.