SLC5A2 and Hyperglycemia: In conditions such as overt hyperglycemia (beyond the renal glucose threshold), genetic loss of glucose transporters like GLUT2 (de Souza Cordeiro et al., 2021; de Souza Cordeiro et al., 2022; Sakamoto et al., 2000) or SGLT2 (Kleta et al., 2004), and/or renal dysfunction, glucose is excreted in the urine.