In univariate analysis, clinical factors related to the occurrence of acute radiation pneumonia included smoking status, weight loss, radiation modality, obstructive pneumonitis, and interstitial pneumonitis; The clinical factors associated with the occurrence of chronic radiation pneumonia included smoking status, epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) status, chemotherapy modality, radiation modality, obstructive pneumonitis, and interstitial pneumonitis. This evidence concerns the gene EGFR and radiation pneumonitis.