CCL2 and cryptococcosis: The observation of less cell infiltration to brain tissues of 5-LO−/− mice in the histopathology and decreased levels of CCL2 and CCL3 levels in brain homogenates of 5-LO−/−, compared to C57BL/6 mice during pulmonary infection with C. deneoformans, led us to evaluate the impact of host-derived 5-LO using a systemic mouse model of cryptococcosis.