No differences in the production of TNF-α, IL-6, IFN-γ, and IL-17, cytokines associated with a positive outcome in IRIS patients (22, 23), were detected in brain homogenates of 5-LO−/− mice compared to C57BL/6 mice at day 35 post-infection (Fig. 4C through F). This evidence concerns the gene IFNG and infection.