PRKAG2 and congestive heart failure: Congestive heart failure (CHF), arrhythmia, and sudden cardiac death (SCD) are common.(4,5) The syndrome was mapped to the locus 7q36 by MacRae et al.(6) and Gollob et al.(1) the gene responsible for the regulatory subunit (PRKAG2) of the 5’ AMP-activated protein kinase (AMPK).