However, breast cancer, oral cancer, hepatocellular cancer, and colorectal and pancreatic cancers have decreased expression of perilipin, which is associated with poor survival and increased invasion.35,47–49 Increased expression of perilipin 1 in AC was observed compared to that in AB.27 Other cytoplasmic markers, Nestin, FASN, NF-kB, BCL-XL, p63 Adipophilin, and COX2, were shown to be overexpressed in AC as compared to AB. The gene discussed is NES; the disease is hepatocellular carcinoma.