APOE and Alzheimer disease: This profile is similar to individuals with preclinical (amyloid-β +) or elevated genetic risk (e.g., APOE-ε4+) for AD (Bookheimer et al., 2000; Filippini et al., 2009; Sperling et al., 2009; Mormino et al., 2011; Schultz et al., 2017).