Cognitive impairment has been associated with such anti-ARHGAP26 autoantibodies and is mainly detected in diseases entailing cerebellar ataxia associated with immunopathology in cerebellar structures (Doss et al., 2014; Jarius and Wildemann, 2015; Bartels et al., 2018). The gene discussed is ARHGAP26; the disease is aceruloplasminemia.