A similar approach might also be useful in other conditions with HTRA1 involvement such as neurodegenerative diseases (Shorter, 2017), age-related macular degeneration (Gerhardy et al., 2022) and TGFβ-induced protein (TGFBIp)-linked corneal dystrophies (Nielsen et al., 2020). Here, HTRA1 is linked to corneal dystrophy.