As reported in many studies, age (Middleton et al., 2007; Hughes et al., 2014; Hamer et al., 2018; Lavrencic et al., 2018b); ApoE-ε4 alleles (Tervo et al., 2004; Kryscio et al., 2006; Luck et al., 2010; Lipnicki et al., 2016); being widowed, divorced, or living alone (Jia et al., 2020); brain atrophy (Jack et al., 2005; van Loenhoud et al., 2019); and depressive symptoms (Gao et al., 2013) are positively associated with conversion to MCI in our cohort. Here, APOE is linked to Brain atrophy.