APOE and sleep disorder: As a result, regardless of their causal relationship, we found that certain neuropsychiatric AEs, namely “delusion,” “confusional state,” “muscle spasms,” “irritability,” “sleep disorder,” or “convulsion,” may be reported more frequently by individuals with the APOE-ε4 allele[s] among placebo arm during RCTs [Table 3, Model (1)].