Consistent with these findings, emerging clinical investigations reveal that ALF during longer delays (1 week to 6 months) is one of the earliest cognitive changes that occur at an asymptomatic stage in ApoE ε4 carriers (Zimmermann and Butler, 2018; Tort-Merino et al., 2021a) and individuals with familial AD (FAD) (Weston et al., 2018; O'Connor et al., 2020; Yang et al., 2021) or subjective cognitive decline (SCD) (Manes et al., 2008; Tort-Merino et al., 2021b), who are still normal in standard or short-term memory tests (Figure 1). Here, APOE is linked to Schnyder corneal dystrophy.