The interaction of SARS-CoV envelope amyloid with IAPP (Ghosh et al., 2015), an identical SARS-CoV-2 envelope protein region and the presence of IAPP in amyloid plaques associated with AD (Jackson et al., 2013) raises the possibility of an interaction between the SARS-CoV-2 envelope protein and amyloid plaques in AD. The gene discussed is ERVW-1; the disease is Alzheimer disease.