Prior studies in AD transgenic mice have produced inconsistent results concerning the effect of familial AD mutations on AHN (Jin et al., 2004; Wen et al., 2004; Kuhn et al., 2007; Taniuchi et al., 2007; Verret et al., 2007; Niidome et al., 2008; Yu et al., 2009; Chuang, 2010; Demars et al., 2010; Elder et al., 2010; Krezymon et al., 2013; Unger et al., 2016), including in the APP/PS1 mice studied here (Taniuchi et al., 2007; Verret et al., 2007; Niidome et al., 2008; Yu et al., 2009; Chuang, 2010; Unger et al., 2016). This evidence concerns the gene APP and Alzheimer disease.