Given the behavioral benefits of BCI-838 in multiple types of proteopathies (Perez-Garcia et al., 2023) its apparent similarity to ketamine regarding mTOR modulation, and the role for mTOR in autophagy, we propose that, like ketamine, BCI-838 exerts its actions through protein translation and autophagy. The gene discussed is MTOR; the disease is proteostasis deficiencies.