However, when APP/PS1 combination was compared with APP/PS1 + PE, we identified 772 DEGs, which were found to be enriched in EIF3K and REST transcription factors, both shown to regulate the mTOR signaling pathway in adipocyte yeast (Harris et al., 2006) and oral cancer cells (Cho et al., 2015), respectively. Here, REST is linked to lip and oral cavity carcinoma.