Pathological hallmarks of AD include the deposition of amyloid β (Aβ) aggregates and the presence of neurofibrillary tangles of hyperphosphorylated tau proteins in brain tissues, leading to neuronal atrophy and death through excitotoxicity, neuroinflammation, defective calcium homeostasis, oxidative stress and energy depletion (lo Cascio et al., 2019; Silva et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.