These results indicated that Nrf2 overexpressing MSCs promoted specific activation of the SDF-1/CXCR4 signaling axis and triggered downstream phosphorylation of the PI3K/AKT and ERK pathways, which laid an experimental foundation for exploring the possible mechanisms of leukemia cell migration and invasion and provided a reference to inhibit the infiltration of B-ALL into extramedullary organs (Figure 7). The gene discussed is NFE2L2; the disease is precursor B-cell acute lymphoblastic leukemia.