It is suggested that after Nrf2 overexpressed MSCs were co-cultured with Nalm-6/RS4; 11 cells, CXCR4 on Nalm-6/RS4; 11 cell surface can be an important factor activating the SDF-1/CXCR4 axis within the leukemia microenvironment, which further promotes Nrf2 overexpressed MSCs to react with ALL cells (Teicher and Fricker, 2010). This evidence concerns the gene NFE2L2 and acute lymphoblastic leukemia.