AKT1 and Alzheimer disease: Aβ25-35 and D-gal-induced AD rats and Aβ25-35-induced PC12 cells were applied to investigated the anti-AD effects of Kai-Xin-San, and the results demonstrated that KXS could be effective in ameliorating AD through multiple mechanisms including regulating neurotransmitters and the PI3K/Akt signal pathway (Guo et al., 2019).