The Kleeb Bua Daeng formula (KBD), a Thai traditional medicine with multi-target activities could inhibit activities of the AChE, Aβ aggregation, the expression of pro-apoptotic factors in an in vitro study (Chheng et al., 2020)and show protective effects on memory impairment in animals (Waiwut et al., 2022). Here, ACHE is linked to memory impairment.