Gut dysbiosis exacerbated AD pathologies and cognitive deficits by activating the Ccaat/Enhancer binding proteinβ(C/EBPβ)/AEP signaling pathway in mouse models (Chen et al., 2022), which was documented to mediate neuroinflammation in AD pathologies (Wang et al., 2018). This evidence concerns the gene CEBPB and Alzheimer disease.