Gut dysbiosis exacerbated AD pathologies and cognitive deficits by activating the Ccaat/Enhancer binding proteinβ(C/EBPβ)/AEP signaling pathway in mouse models (Chen et al., 2022), which was documented to mediate neuroinflammation in AD pathologies (Wang et al., 2018). The gene discussed is LGMN; the disease is Alzheimer disease.