St Croix et al. (2000) also identified a role for IGFBP7 in binding to Type IV collagen protein. They demonstrated elevated expression of IGFBP7 compared to healthy endothelial cells, suggesting IGFBP7 as a potential tumor endothelial cell marker, as determined by serial analysis of gene expression. The gene discussed is IGFBP7; the disease is neoplasm.