IGFBP7 is associated with the pathophysiology of endometriosis, as serum IGFBP7 concentrations in patients with endometriosis are significantly higher than those in the control group (Kutsukake et al., 2008), and metformin can upregulate the expression of IGFBP7 in both human and mouse models of endometriosis (Huang et al., 2022). The gene discussed is IGFBP7; the disease is endometriosis.