The interaction between TDP-43 and tRNAPhecould be of physiological relevance given that a point mutation of human tRNAPhecauses MERRF myopathy characterized by cytoplasmic inclusions containing TDP-43(Mancuso et al., 2004)and that aminoacylation of tRNAPheis compromised in ALS patients (Malnar Črnigoj et al., 2023). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.