In humans, TDP-43 is involved in fatal neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration FTLD(Neumann et al., 2006), as well as in myodegenerative diseases such as sporadic inclusion bodies myositis sIBM(Cortese et al., 2014)and myoclonic epilepsy associated with ragged red fibers MERRF(Mancuso et al., 2004; Mori et al., 2019). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.