SERPINE1 and obstructive sleep apnea syndrome: Oxidative stress responses leading to tissue ischemia and hypoxia, including ROS, vascular endothelial growth factor (VEGF), advanced glycosylation end products (AGEs), and plasminogen activator inhibitor-1 (PAI-1), have been identified in individuals with Obstructive sleep apnea hypopnea syndrome (OSAHS), potentially contributing to the onset and progression of vascular disease (Yamamoto et al., 2008; Assoumou et al., 2012).