Niemann–Pick type C (NPC) (NPC1, MIM 257220) disease is a rare, genetically determined, autosomal, recessive neurodegenerative, neurovisceral storage disorder caused by mutations in the NPC1 gene (95%) or, only rarely, in the NPC2 gene (5%) that lead to the progressive neurodegeneration of the central nervous system (Sleat et al., 2004; Millat et al., 2005; Vanier, 2010; Newton et al., 2018; Lee et al., 2020). Here, NPC1 is linked to nasopharyngeal carcinoma.