As COVID-19 severity increased, there were corresponding rises in infection indicators like white blood cell (WBC) count, neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP), serum amyloid A (SAA), and inflammatory mediators such as interleukin-6 (IL-6) and interleukin-10 (IL-10). The gene discussed is CRP; the disease is infection.