A selective SIK2 inhibitor ARN-3236 restricts fibroblasts differentiation and ECM gene expression in human fetal lung fibroblasts and attenuates bleomycin-induced pulmonary fibrosis in mice (Zou et al., 2022), supporting as pathological role for SIK2 in pulmonary fibrosis. Here, SIK2 is linked to pulmonary fibrosis.