On HS condition, Sik1 deletion leads to increased BP and vascular remodeling, as indicated by higher systolic BP, upregulation of TGFβ1 signaling, increased expression of endothelin-1 and genes related to VSMC contraction, and signs of cardiac hypertrophy (Bertorello et al., 2015). The gene discussed is SIK1; the disease is cardiac hypertrophy.