Although we cannot rule out the possibility that additional genetic and environmental modifiers contribute to a markedly milder phenotype,32 a similar observation was identified in a family with established ADPKD-GANAB,33 where it is possible that age-related increase in the simple kidney cysts, which are linked to impaired kidney function and CKD, may have contributed to cysts formation.32 This evidence concerns the gene GANAB and chronic kidney disease.