Twelve glycoproteins differed significantly in abundance between clinically affected and clinically unaffected heterozygous R79W-ALG5 individuals (Figure 8b and Supplementary Table S5).S9–S16 All these proteins are involved in the complement and coagulation cascade (AMBP, APOA4, CD5L, CFD, HP, and KNG1), inflammatory response (CD5L, CFD, HP, and KNG1), protein folding (HSPA8) and are associated with kidney diseases (AMBP, APOA4, CD5L, CFD, HP, KNG1, LRG1, LUM, SERPINF1, and RBP4) (Figure 8c). Here, ALG5 is linked to kidney disorder.