ALG5 and chronic kidney disease: Therefore, plasma samples of 6 individuals with heterozygous R79W-ALG5 variant- and CKD (clinically affected), 8 individuals with heterozygous R79W-ALG5 variant and an eGFR >60 ml/min per 1.73 m2 (clinically asymptomatic) and 10 family members with WT-ALG5 (genetically unaffected) from F350 were analyzed (Figure 7).