Although we cannot rule out the possibility that additional genetic and environmental modifiers contribute to a markedly milder phenotype,32 a similar observation was identified in a family with established ADPKD-GANAB,33 where it is possible that age-related increase in the simple kidney cysts, which are linked to impaired kidney function and CKD, may have contributed to cysts formation.32 The gene discussed is GANAB; the disease is Kidney Cyst.