Subjects F200_II.5 (aged 67 years [eGFR: 57 ml/min]; Figure 2 Panel D and E) and F350_II.7 (aged 69 years (eGFR: 79 ml/min); figures not shown), neither harboring the heterozygous R79W-ALG5 variant, have a few scattered liver and kidney cysts. This evidence concerns the gene ALG5 and Complex Cyst of Kidney.