PKD2 and autosomal dominant polycystic kidney disease: Abnormal and impaired N-glycosylation of PC1 likely affects normal cell-cell interactions and induces cyst formation, as is seen in ADPKD-PKD1 and PKD2. Although abnormal glycosylation leads to cystic changes, they are mild in comparison to those found in ADPKD and do not appear alone enough to lead to ESKD.