TP53 and adrenal cortex carcinoma: Several molecular parameters such as Wnt/β-catenin pathway alterations increased p53 expression, insulin growth factor-II overexpression, hypermethylation of CpG loci, and overexpression of several miRNAs allow classifying these tumors based on their genetic profile either in the C1A (poor outcome ACC) or C1B (better outcome ACC) group (14, 24) (Fig. 5).