In univariate analysis, the rising high group had more women (66.7% vs 32.0%; P = 0.003), more chronic kidney disease (33.3% vs 13.7%; P = 0.031), higher serum creatinine on Day 3 (1.24 vs 0.93 mg/dL; P = 0.032), higher urinary NGAL on Day 3 (131.5 vs 49.6 ng/mL; P = 0.002), longer hospital stay (38 vs 22 days; P = 0.006), and higher mortality rate (16.7% vs 0.7%; P < 0.001). Here, LCN2 is linked to chronic kidney disease.