These results have been replicated in Sprague-Dawley rats 10 weeks after ovariectomy, with results showing an induction in anxiety- and depression-like behaviors in the FST, sucrose preference test, elevated plus maze, and novelty-suppressed feeding test, while simultaneously increasing proinflammatory cytokines, neural apoptosis and microglial activation from immunoregulatory to proinflammatory phenotype in the hippocampus and reinforced NFκB (134, 135). The gene discussed is NFKB1; the disease is depressive disorder.