NFKB1 and major depressive disorder: These results have been replicated in Sprague-Dawley rats 10 weeks after ovariectomy, with results showing an induction in anxiety- and depression-like behaviors in the FST, sucrose preference test, elevated plus maze, and novelty-suppressed feeding test, while simultaneously increasing proinflammatory cytokines, neural apoptosis and microglial activation from immunoregulatory to proinflammatory phenotype in the hippocampus and reinforced NFκB (134, 135).