Cytokine‐induced SH2 protein (CISH), a member of the cytokine signaling inhibitor (SOCS) family CISH is a novel intracellular immune checkpoint that regulates T‐cell signaling and function, and studies have shown that knockdown of CISH in CD8(+) T cells using CRISPR/Cas9 improves the immunotherapeutic efficacy of cancer.401. Here, CISH is linked to cancer.