After transplantation of CRISPR–Cas9‐edited autologous CD34+ cells targeting the BCL11A enhancer, SCD patients with βS/βS and a single α‐bead protein deletion had high levels of allelic editing in both bone marrow and blood, and the patients’ fetal hemoglobin levels increased to 43.2% and sickle hemoglobin to 52.3% at month 15. The gene discussed is BCL11A; the disease is Schnyder corneal dystrophy.