Using CRISPR/cas9, a 1bp insertion at amino acid 311 of the hamster TP53 gene was used to construct a TP53 KO hamster model, in which TP53‐pure mutant hamsters suffer from a variety of cancers, including lymphomas and myeloid leukemia, and TP53‐heterozygous mutants suffer from aggressive acute myeloid leukemia (AML), and could be used as a complementary model to the existing mouse model.178. Here, TP53 is linked to myeloid leukemia.