GCK and Glucose intolerance: Mutations in glucokinase (GCK), which is used for glucose sensing and glucose regulation, induce maturity‐onset diabetes of the young type 2 (MODY‐2), and because GCK KO mice die within 2 weeks of birth and cannot be used for preclinical studies, a study has developed a diabetic rabbit model using CRISPR/Cas9 to produce a nonshift coding mutation (GCK‐NFS) in the GCK gene, which produces hyperglycemia and glucose intolerance typical of MODY‐2 patients, and is a valuable rabbit model for preclinical studies of diabetes mellitus.183