LCA is mainly caused by gene mutations, among which a deep mutation in intron 26 of the CEP290 gene (c.2991+1655A>G, IVS26 mutation) in LCA10 patients is the most common causative mutation in LCA, which leads to incorrect splicing and early generation of the stop codon affecting protein expression.348. Here, CEP290 is linked to Leber congenital amaurosis.