Studies have crossed transgenic β‐YAC mice with C57BL/6 mice expressing the human CD46 genomic locus to generate β‐YAC/CD46 mice for in vivo and in vitro HSPC transduction experiments, could be used for SCD and β‐thalassemia studies.151, 152, 153, 154. The gene discussed is CD46; the disease is Schnyder corneal dystrophy.