Recent investigations have reported that anti-glial autoantibodies can occur in AD (Lim et al., 2019), and that potassium voltage-gated channel subfamily A member 2 (KCNA2) autoantibodies may coincide with a CSF-based AD pathology (AP) (Timäus et al., 2021). This evidence concerns the gene KCNA2 and Alzheimer disease.