The SNP rs744373 is the most commonly reported BIN1 variant conferring AD risk, with an Odds Ratio (OR) of 1.17–1.19 and a global frequency close to 40% (Antúnez et al., 2011; Hu et al., 2011; Almeida et al., 2018). The gene discussed is BIN1; the disease is Alzheimer disease.