Patients with LS are typically asymptomatic but can present with paresthesia, pruritus, and pain [2], in contrast with LA, where there are additional abnormalities related to hair growth [1]. The pathogenesis of both LS and LA is not well understood; however, some cases have reported an association with possible hormone leptin dysregulation and/or hyperlipidemia [3]. This evidence concerns the gene LEP and Leigh syndrome.