There was a close correlation between mean Lp(a), ApoB/ApoA-I ratio, and LDL-C/HDL-C ratio with serum glucose, blood HbA1C, and HOMA-IR in individuals with prediabetes. The study's findings could pave the way for longitudinal studies to track changes in lipoprotein ratios over time and their impact on diabetes progression and cardiovascular outcomes. The gene discussed is APOA1; the disease is prediabetes syndrome.