Significant predictors included maximum intraoperative lactate level [odds ratio (OR): 1.423, 95% CI: 1.258–1.609; P < 0.001], age (OR: 1.248, 95% CI: 1.136–1.372; P < 0.001), atrial fibrillation (OR: 2.183, 95% CI: 1.266–3.762; P = 0.05), intraoperative cryoprecipitate transfusion volume (OR: 1.111, 95% CI: 1.055–1.170; P < 0.001), ASA classification ≥3 (OR: 2.929, 95% CI: 1.680–5.105; P < 0.001), MPV (OR: 1.148, 95% CI: 1.350–1.610; P = 0.015), and higher BNP levels (BNP 100–400 vs. BNP < 100, OR: 1.674, 95% CI: 1.011–2.771; BNP >400 vs. BNP < 100, OR: 2.220, 95% CI: 1.251–3.938). The gene discussed is NPPB; the disease is atrial fibrillation.