The BRAF V600E mutation has been reported in GG, polymorphous low-grade neuroepithelial tumor of the young (PLNTY), pleomorphic xanthoastrocytoma, pilocytic astrocytoma, DNT, and MAPK pathway-altered diffuse low-grade glioma (dLGG). The gene discussed is BRAF; the disease is pilocytic astrocytoma.