Another complex candidate is ECI-006, which carries a combination of three mRNAs for dendritic cell (DC) activating molecules such as CD40L, CD70 and caTLR4 (TriMix), and several mRNAs encoding for melanoma TAAs such as tyrosinase, gp100, MAGE-A3, MAGE-C2, and PRAME. The gene discussed is TYR; the disease is melanoma.