A diminished MGAT1 signature in moderately differentiated HCC correlates with tumor dedifferentiation, intrahepatic migration, and a poor clinical prognosis (108).This observation aligns with our spatial-temporal analysis, which showed a decrease in MGAT1 expression from cluster 1 to cluster 6, followed by a resurgence as the transition progressed from cluster 1 to cluster 6 and subsequently to cluster 3. The gene discussed is MGAT1; the disease is hepatocellular carcinoma.