It’s worth noting that the BTK inhibitor (G-744) has been found to halt plasma cell generation in spontaneous and IFNα-accelerated NZB/W_F1 lupus models (174), while SYK has been shown to be pivotal in B cell antibody responses, memory B cell survival, and plasma cell proliferation (175, 176). Here, IFNA1 is linked to systemic lupus erythematosus.