In addition, researchers using mass cytometry to study immune cell dysregulation in peripheral blood samples from active SLE (aSLE), remission SLE (rSLE), and HCs found that the abundance and dysfunction of CD8+CD27+CXCR3−T cells could be potential biomarkers for SLE prognosis and concomitant diagnosis (75). This evidence concerns the gene CD27 and systemic lupus erythematosus.