In line with these findings, recent studies have pointed out that Jingfang Granules (JFG) can increase the expression of AMPK and SIRT1 by promoting the phosphorylation of LKB1 and AMPK, thereby inhibiting the activation of NLRP3, inhibiting OVA/aluminum hydroxide-induced skin inflammation, and alleviating Urticaria disease symptoms (94). Here, NLRP3 is linked to urticaria.