While SIRT1 levels in keratinocytes and dermal fibroblasts are upregulated, HDAC6 and CXCL13 levels are also upregulated to aggravate the inflammatory response of specific dermatitis, which is involved in the increased expression of Th1 and Th2 cytokines and the downregulation of Foxp3 and IL-10. The gene discussed is SIRT1; the disease is dermatitis.