The incidence of each type of irAEs is shown in the Figure 7B: the most common any-grade irAEs were RCCEP (44.8%), fatigue (28.9%), hyperbilirubinemia (28.8%), elevated AST (25.0%), proteinuria (23.2%), elevated alanine aminotransferase (ALT) (22.9%), hand–foot skin reaction (22.1%), hypertension (21.8%), thrombocytopenia (19.7%), and fever (19.4%). This evidence concerns the gene GPT and Hyperbilirubinemia.