Acute kidney injury occurs in 60% of sepsis patients,[18] and the use of vasopressors may result in vasoconstriction and increased kidney injury.[1,29] In our study, we selected a panel of markers to capture cardinal features of acute kidney injury, but there were no significant differences in the urine output, tubular injury score, KIM-1, NGAL, cytokine, and COL1A1 between the metaraminol and norepinephrine groups. The gene discussed is LCN2; the disease is acute kidney injury.